Note that some Office add-ons, like for Excel, are installed directly in the user profile, so can't be layered. When using add-ons in separate layers, it is recommended to include all previously included add-ons also as prerequisites to ensure that they will work together properly if they will ever be deployed together. If you use Office Add-ons, these should be included in the office layer, but can sometimes be installed in different layers with Office checked as a prerequisite layer during layer creation. If your organization's requirements are more complicated, then there will be more things to keep in mind. Microsoft Office is an application that is generally easy to install into a layer, and, if it will be used by itself, there are no complexities other than activation. Citrix App Layering - Microsoft Office Overview